Planta Med 2003;69(12):1113-1118. View abstract. Fiore, C., Eisenhut, M., Krausse, R., Ragazzi, E., Pellati, D., Armanini, D., and Bielenberg, J. Antiviral effects of Glycyrrhiza species. View abstract. Zhong Xi Yi Jie He Za Zhi 1990;10:101-2, 70. . Hattori, T., Ikematsu, S., Koito, A., Matsushita, S., Maeda, Y., Hada, M., Fujimaki, M., and Takatsuki, K. Preliminary evidence for inhibitory effect of glycyrrhizin on HIV replication in patients with AIDS. View abstract. [Treatment of chronic hepatitis B. Liu C, Wang J, Yang J. Drugs & Vitamins . J Contemp Dent Pract 2010;11(1):E088-E094. This can be severe. Other conditions. The treatment of human cancer with agents prepared from bovine cartilage. View abstract. Eur J Drug Metab Pharmacokinet. Migraine is a type of headache. Case Rep Emerg Med. View abstract. View abstract. Severe hypokalaemia with paralysis induced by small doses of liquorice. View abstract. Chamberlain, J. J. and Abolnik, I. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. Ir J Med Sci 2016;185(4):945-7. Licorice might decrease the effects of warfarin. Effect of orally administered shao-yao-gan-cao-tang (Shakuyaku-kanzo-to) on muscle cramps in maintenance hemodialysis patients: a preliminary study. Strandberg TE, Andersson S, Jarvenpaa AL, et al. 2017 Sep;31(9):1330-1340. Lee, C. H., Park, S. W., Kim, Y. S., Kang, S. S., Kim, J. Beretta-Piccoli, C., Salvade, G., Crivelli, P. L., and Weidmann, P. Body-sodium and blood volume in a patient with licorice-induced hypertension. View abstract. A double-blind, randomized, placebo-controlled, multicenter trial. A multicentre trial. Hum.Exp Toxicol. View abstract. Pak J Med Sci 2022;38(1):271-275. View abstract. Yang DG. To learn more about how herbs are used to treat infertility, see this article. Because of its beneficial effects, the licorice root has been dubbed the "Medicinal plant of 2012." Now scientists have discovered that licorice root from the papilionaceae or leguminous family . View abstract. J Hypertens 1985;3(1):19-23. Licorice seems to change hormone levels in the body. N Engl J Med 1991;325:1223-7. B. Licorice-associated reversible cerebral vasoconstriction with PRES. View abstract. J Am Acad Dermatol 2011;65(4):699-714. Paeonia lactiflora (Chinese peony) and Paeonia brownii (California peony) relax smooth muscle tissue with a particular affinity for the female reproductive tract. Immunopharmacology 1999;41(3):169-181. Most clinical trials have found that when Peony is combined with Licorice Rt. 2000;19(8):434-439. Zhang W, Leonard T, Bath-Hextall F, et al. Akbari N, Asadimehr N, Kiani Z. . Zhang YD, Lorenzo B, Reidenberg MM. Am J Chin Med 2005;33(5):747-758. Neth J Med 2005;63:146-8. The effects of licorice containing diphenhydramine solution on recurrent aphthous stomatitis: A double-blind, randomized clinical trial. Deglycyrrhizinated liquorice in duodenal ulcer. Low doses of liquorice can induce hypertension encephalopathy. Hossain, M. S., Takimoto, H., Hamano, S., Yoshida, H., Ninomiya, T., Minamishima, Y., Kimura, G., and Nomoto, K. Protective effects of hochu-ekki-to, a Chinese traditional herbal medicine against murine cytomegalovirus infection. Int J Dermatol 1999;38:387-92 . Lee YS, Lorenzo BJ, Koufis T, et al. View abstract. Clinical application of compound Glycyrrhizin tablets in the treatment of patients with Simplex Henoch-Schonlein Purpura and its effect on immune function. Ai, M., Yamaguchi, T., Odaka, T., Mitsuhashi, K., Shishido, T., Yan, J., Seza, A., and Saisho, H. Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy. View abstract. Wu, T. H., Chiu, T. Y., Tsai, J. S., Chen, C. Y., Chen, L. C., and Yang, L. L. Effectiveness of Taiwanese traditional herbal diet for pain management in terminal cancer patients. Prevention of maternal-fetal blood group incompatibility with traditional Chinese herbal medicine. View abstract. View abstract. Zhong.Xi.Yi.Jie.He.Za Zhi. Licorice that has had this substance removed (called DGL for deglycyrrhizinated licorice) may not have the same degree of side effects. 2017 Apr 1;27(2):150-154. doi: 10.1684/ejd.2016.2946. Saw palmetto might make your risk of bleeding higher if you also take a blood thinner, such as: Aspirin; Clopidogrel; Warfarin; St. John's wort. Sigurjonsdottir HA, Franzson L, Manhem K, et al. Side effects of peony tea! Zhou Y, Jin L, Kong F, et al. . Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. Biol Pharm Bull 1998;21:1277-81. 2013 Sep;117(3):614-21. About Dr.Cope. Madisch A, Holtmann G, Mayr G, et al. View abstract. Patients received either bromocriptine 5 mg daily for 4 weeks followed by 4 weeks of 22.5 grams daily of the peony-licorice decoction (equivalent to 25 mg of glycyrrhetinic acid), or the same drugs in the reverse order. J Clin Pharm Ther 2001;26:271-8. Au, T. K., Lam, T. L., Ng, T. B., Fong, W. P., and Wan, D. C. A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs. The roots are commonly used in Traditional Chinese Medicine (TCM) for many purposes. A., Braun, T. M., and Jacobson, J. J. Aliment Pharmacol Ther 2004;20:1279-87. View abstract. View abstract. Dong quai grows at high altitudes in the cold, damp, mountains of China, Korea, and Japan. Best Underarm Whitening Creams For You 1. J Hum Hypertens 2001;15:549-52. Ruiz-Granados, E. S., Shouls, G., Sainsbury, C., and Antonios, T. A salty cause of severe hypertension. Licorice that has the active ingredient of glycyrrhiza can have serious side effects. Phytother Res 2008;22(6):709-724. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. View abstract. 2 in the perioperative stage of laparoscopic cholecystectomy]. Liu X, Li X, Li X, et al. Phytother Res. Can J Cardiol 2009;25(10):e357-e358. Pharmacol Biochem Behav 1993;45:719-23. . View abstract. Hypertension and the cortisol-cortisone shuttle. Warfarin is used to slow blood clotting. Pseudohyperaldosteronism, liquorice, and hypertension. 10. Feng ZT, Xu J, He GC, Cai SJ, Li J, Mei ZG. Chemical studies of Chinese licorice-roots. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Radix Paeoniae Alba increases serum estrogen level and up-regulates estrogen receptor expression in uterus and vagina of immature/ovariectomized mice. Erratum in: Clin Rheumatol. Brush, J., Mendenhall, E., Guggenheim, A., Chan, T., Connelly, E., Soumyanath, A., Buresh, R., Barrett, R., and Zwickey, H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. In general, the safety and effectiveness of alternative medicines have not been scientifically proven and remain largely unknown. Information from this source is evidence-based and objective, and without commercial influence. Hattori, M., Sakamoto, T., Kobashi, K., and Namba, T. Metabolism of glycyrrhizin by human intestinal flora. Peony might have some of the same effects as estrogen. View abstract. Taking licorice and loop diuretics together might make potassium levels drop too low. A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. This might increase the effects and side effects of methotrexate. Taking licorice with paclitaxel might decrease the effects of paclitaxel. Effect of preoperative licorice lozenges on incidence of postextubation cough and sore throat in smokers undergoing general anesthesia and endotracheal intubation. Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. Xu Y, Li X, Chen T, et al. Hypertension encephalopathy after liquorice ingestion. View abstract. Guo, D., Ye, G., and Guo, H. A new phenolic glycoside from Paeonia lactiflora. Burgess, J. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. View abstract. Melzer J, Rosch W, Reichling J, et al. Scali, M., Pratesi, C., Zennaro, M. C., Zampollo, V., and Armanini, D. Pseudohyperaldosteronism from liquorice-containing laxatives. Asia Pac.J Clin Nutr 2008;17(1):17-22. View abstract. View abstract. Takahara T, Watanabe A, Shiraki K. Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. View abstract. View abstract. Licorice root contains glycyrrhizin, which can cause side effects when eaten in large amounts. View abstract. Endocrinol Jpn 1990;37:331-41. Heidemann HT, Kreuzfelder E. Hypokalemic rhabdomyolysis with myoglobinuria due to licorice ingestion and diuretic treatment. BMJ Case Rep. 2012 Oct 19;2012. Peony-glycyrrhiza decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. View abstract. A man in Massachusetts died after eating too much black licorice, which contains a compound known to be toxic in large doses, according to a new report. Kim YR, Nam SH. The immediate effect of Shakuyaku-kanzo-to, traditional Japanese herbal medicine, for muscular cramps during maintenance hemodialysis. View abstract. Ha Y, Wang T, Li J, et al. Endocrinol Jpn 1991;38(2):167-174. Shintani, S., Murase, H., Tsukagoshi, H., and Shiigai, T. Glycyrrhizin (licorice)-induced hypokalemic myopathy. Mol Nutr Food Res 2006;50(11):1080-1086. View abstract. Grapefruit juice and its flavonoids inhibit 11 beta-hydroxysteroid dehydrogenase. View abstract. Zhongguo Zhong.Xi.Yi Jie.He.Za Zhi 2008;28(4):358-360. Pakravan F, Salehabad NH, Karimi F, Isfahani MN. Oral Dis 2012;18(1):32-39. Mamgain RK, Gupta M, Mamgain P, et al. 2011;25(1-2):21-38. Aging Clin Exp Res. Select a condition to view a list of vitamins. View abstract. Guo, T. L. and Zhou, X. W. [Clinical observations on the treatment of the gestational hypertension syndrome with Angelica and Paeonia powder]. Robles BJ, Sandoval AR, Dardon JD, Blas CA. Exp Clin Endocrinol Diabetes 2003;111:341-3. Rosenblat, M. and Aviram, M. Paraoxonases role in the prevention of cardiovascular diseases. Phytother.Res 2004;18(3):241-243. View abstract. View abstract. Chen, W. G. and Ba, Z. M. Prof. ZHANG Yi's experience in treating severe arrhythmia. Bannister, B., Ginsburg, R., and Shneerson, J. Cardiac arrest due to liquoriceinduced hypokalaemia. Exp.Mol.Med 12-31-2003;35(6):467-474. Effects of Paeoniae Radix, a traditional Chinese medicine, on the pharmacokinetics of phenytoin. 1987;(10):46-48. Cai Y, Yuan Q, Xu K, et al. Riv Patol Nerv Ment 1983;104(4):179-183. View abstract. Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). View abstract. Objective: To evaluate the effect of different ratio of peony and licorice and Christina Loosestrife herb decoction on isolated in New Zealand . J Pharm Pharmacol 2003;55:1275-82. Wang Y, Ma R. [Effect of an extract of Paeonia lactiflora on the blood coagulative and fibrinolytic enzymes]. View abstract. The anti-estrogenic action of beta-glycyrrhetinic acid. View abstract. View abstract. Diane Calello, executive medical director of the New Jersey Poison Control Center, based at Rutgers New Jersey Medical School, discusses safe . [Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration]. 1986;6(12):714-6, 707. Bruynzeel DP. But not everyone will have the side . Treatment of duodenal ulcer with glycyrrhizinic-acid-reduced liquorice. Some believe it may also increase estrogen and prolactin levels in women, though more research is warranted. All rights reserved. View abstract. BMJ Case Rep. 2013 Sep 19;2013. 2020;2020:8401239. Kang, D. G., Moon, M. K., Choi, D. H., Lee, J. K., Kwon, T. O., and Lee, H. S. Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway. Pfeifer BL, Pirani JF, Hamann SR, Klippel KF. Li G, Simmler C, Chen L, et al. However, taking too much licorice root may cause side effects. Anti Erection Pill. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. View abstract. Asl, M. N. and Hosseinzadeh, H. Review of pharmacological effects of Glycyrrhiza sp. View abstract. Medicine (Baltimore) 2018;97(11):e0073. J Altern Complement Med 2000;6:557-9. The herb has also been studied for use in canine atopic dermatitis along with white peony (Paeonia lactiflora) and licorice (Glycyrrhiza glabra). Proanthocyanidins, flavonoids, tannins, polysaccharides, and paeoniflorin are all considered to contribute to the medicinal activity of various forms of peony. Meng Xiangrui is an academic researcher. . Contact Dermatitis 1989; 20:152-3.. View abstract. Martin, M. D., Sherman, J., van der Ven, V., and Burgess, J. Ma, X. F. [Experimental and clinical studies on the treatment of pulmonary heart disease and pulmonary hypertension with Paeonia lactiflora]. Cancer Res 2000;60:5704-9.. View abstract. Chang GH, Lin YS, Hsu KH, et al. Therapeutic Research Faculty 2020. Oh, G. S., Pae, H. O., Choi, B. M., Jeong, S., Oh, H., Oh, C. S., Rho, Y. D., Kim, D. H., Shin, M. K., and Chung, H. T. Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells. Badr, A. E., Omar, N., and Badria, F. A. Arase, Y., Ikeda, K., Murashima, N., Chayama, K., Tsubota, A., Koida, I., Suzuki, Y., Saitoh, S., Kobayashi, M., and Kumada, H. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Nippon Rinsho 1994;52:1817-22. View abstract. View abstract. View abstract. Postgrad Med J 1980;56(657):526-529. J Nat Prod 1980;43(2):259-269. 2001;21(7):501-503. Hasegawa, J., Suyama, Y., Kinugawa, T., Morisawa, T., and Kishimoto, Y. Echocardiographic findings of the heart resembling dilated cardiomyopathy during hypokalemic myopathy due to licorice-induced pseudoaldosteronism. Ann Pharmacother 2003;37(6):836-838. View abstract. As I've all but cut out alcohol, I've tended to drink this tea before going to bed and sometimes during the day. Exp Ther Med 2016;11(3):1135-41. 2020;2020:3727682. Journal of Clinical Therapeutics Medicine. Xu, L., Jiang, J., and Du, F. Z. View abstract. 2019;33(1):117-29. Ou TT, Wu CH, Hsu JD, et al. View abstract. We currently have no information for PEONY overview. Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Bell ZW, Canale RE, Bloomer RJ. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. Am J Psychiatry 1994;151:617-8. Contact Dermatitis 2008;59(1):52. Some sources claim that it's contraindicated during pregnancy . Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. No side effects or changes in liver function tests occurred during the study. Amaryan G, Astvatsatryan V, Gabrielyan E, et al. Effect of glycyrrhizin-containing toothpaste on dental plaque reduction and gingival health in humans. O'Connell, R. L., White, I. R., White, J. M., and McFadden, J. P. Liquorice extract in a cosmetic product causing contact allergy. View abstract. View abstract. Prospective study]. This could change the effects and side effects of these medications. Chinese herbal medicine for atopic eczema. View abstract. View abstract. J Ethnopharmacol 2004;94:339-44. . Antiviral Res 12-11-1988;10(6):289-298. Evid Based Complement Alternat Med. Effects of paeoniflorin on the cerebral infarction, behavioral and cognitive impairments at the chronic stage of transient middle cerebral artery occlusion in rats. View abstract. Therapeutic Research Faculty 2020. View abstract. Jin, C. Y., Wang, D. L., and Fang, Z. D. [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood]. View abstract. Petramfar P, Hajari F, Yousefi G, Azadi S, Hamedi A. Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease, A randomized double blinded clinical trial. Eur.Arch.Paediatr.Dent 2010;11(6):274-278. View abstract. Eur J Dermatol. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. This plant is native to East Asia. Am J Chin Med 2003;31:445-53. . Grebeniuk, V. N., Mannanov, A. M., Korsun, V. F., and Vinogradova, A. I. Lee, S. M., Li, M. L., Tse, Y. C., Leung, S. C., Lee, M. M., Tsui, S. K., Fung, K. P., Lee, C. Y., and Waye, M. M. Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. Life Sci 2-23-2001;68(14):1687-1694. Contact Dermatitis 2021;85(4):454-455. Efficacy of traditional Chinese herbal therapy in adult atopic dermatitis. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. Licorice is available in many different types of products, including candies, lozenges, teas, chewing, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox, Side effects in people after breathing tube removal. Barrella, M., Lauria, G., Quatrale, R., and Paolino, E. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. View abstract. Lapi F, Gallo E, Bernasconi S, et al. Licorice (Glycyrrhizae Radix) 15 g: NR: Zhao (2016) [36] . J Clin Hypertens (Greenwich) 2016;18(2):159-60. Myopathies associated with red yeast rice and liquorice: spontaneous reports from the Italian Surveillance System of Natural Health Products. Title 21. Lancet 2000;355(9198):134-138. We could use compounds in these foods to . View abstract. J Biol Response Mod 1985;4:551-84. Fan ZJ, Liu JM, Li XX, et al. Inflammopharmacology 2022;30(2):477-486. Liang, R., Chen, M. R., and Xu, X. Thom E and Wollan T. A controlled clinical study of kanjang mixture in the treatment of uncomplicated upper respiratory tract infections. Treatment of functional dyspepsia with a herbal preparation. J Ethnopharmacol 2011;135(1):162-72. Paeoniflorin, a constituent of white peony root, has demonstrated inhibition of testosterone synthesis in vitro, without affecting estradiol synthesis.It reduces testosterone production by the ovaries but not the adrenal glands. Clin Neurol Neurosurg 2003;105:286-7.. View abstract. Gallacher SD, Tsokolas G, Dimitropoulos I. Liquorice-induced apparent mineralocorticoid excess presenting in the emergency department.